New Research Identifies Vitamin D Impact on Gene Expression

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Vitamin D – suitable for vegetarians and vegans

Vitamin D now shown to reduce risk of Cancer, Cardiovascular Disease, Infectious Diseases and Autoimmune Diseases.

Improving vitamin D levels in healthy adults has a significant impact on the expression of genes associated with cancer, cardiovascular disease (CVD), infectious diseases and autoimmune diseases, according to a new randomised double-blind pilot trial.(1)

The researchers found statistically significant alterations in the activity of 291 genes related to 160 pathways linked to cancer, autoimmune diseases, infectious diseases and CVD.

Results showed that the vitamin D status of the group receiving 2000 IUs daily increased to sufficient following supplementation, yet the group receiving only 400 IUs daily still had insufficient levels following supplementation.

Lead researcher, Professor Michael Holick from BUSM commented,

“While a larger study is necessary to confirm our observations, the data demonstrates that improving vitamin D status can have a dramatic effect on gene expression in our immune cells, and may help explain the role of vitamin D in reducing the risk for CVD, cancer and other diseases.”

References:
(1) Holick MF, Spira A et al. Influence of Vitamin D Status and Vitamin D3 Supplementation on Genome Wide Expression of White Blood Cells: A Randomised Double-Blind Clinical Trial.  PloS ONE  Published online ahead of print, doi: 10.1371/journal.pone.0058725

Also see : Vitamin D deficiency linked to Diabetes, Cancer and Depression